＜主な論文＞

1. Nao Kodama, Takuma Matsubara, Anna Yoshimura, Kenichi Nagano, Jun Hino, Kunikazu Tsuji, Aoi Ikedo, Yuuki Imai, Tatsuki Yaginuma, Quan Yuan, Kazumasa Morikawa, Yusuke Ono, Tomohiko Shirakawa, William N. Addison, Izumi Yoshioka, Shoichiro Kokabu. BMP3b regulates bone mass by inhibiting BMP signaling. . 2025. 190:117303. doi: 10.1016/j.bone.2024.117303.

2. Qing Jiang, Kenichi Nagano, Takeshi Moriishi, Hisato Komori, Chiharu Sakane, Yuki Matsuo, Zhiguo Zhang, Riko Nishimura, Kosei Ito, Xin Qin, and Toshihisa Komori. Roles of Sp7 in osteoblasts for the proliferation, differentiation and osteocyte process formation. ., 47, 161-175. 2024. doi.org/10.1016/j.jot.2024.06.005.

3. Hiroka Kawaue, Takuma Matsubara, Kenichi Nagano, Aoi Ikedo, Thira Rojasawasthien, Anna Yoshimura, Chihiro Nakatomi, Yuuki Imai, Yoshimitsu Kakuta, William N. Addison, Shoichiro Kokabu, KIF22 regulates mitosis and proliferation of chondrocyte cells., 27, 110151, 2024. doi.org/10.1016/j.isci.2024.110151.

4. Kenichi Nagano, Kei Yamana, Hiroaki Saito, Riku Kiviranta, Ana Clara Pedroni, Dhairya Raval, Christof Niehrs, Roland Baron, Francesca Gori. R-spondin 3 deletion induces Erk phosphorylation to enhance Wnt signaling and promote bone formation in the appendicular skeleton. eLife. 11:e84171. 2022. doi: 10.7554/eLife.84171.

5. Annika Treyball, Audrey C Bergeron, Daniel J Brooks, Audrie L Langlais, Hina Hashmi, Kenichi Nagano, Deborah Barlow, Ryan J Neilson, Tyler A Roy, Kathleen T Nevola, Karen L Houseknecht, Roland Baron, Mary L Bouxsein, Anyonya R Guntur, Katherine J Motyl. Propranolol promotes bone formation and limits resorption through novel mechanisms during anabolic parathyroid hormone treatment in female C57BL/6J mice. 2022 May;37(5):954-971. doi: 10.1002/jbmr.4523.

6. [Case Report] Shun Narahara, Eiji Mitate, Naoya Murayama, Yutaka Kuwatsuka, Hiroyuki Murota, Kenichi Nagano, Naoki Katase, Shuichi Fujita, Izumi Asahina. A case of lymphomatoid papulosis arising on the upper lip. 2021 July; 33(4):420-424.doi: 10.1016/j.ajoms.2021.01.003.

7. Vappu Nieminen-Pihala, Kati Tarkkonen, Julius Laine, Petri Rummukainen, Lauri Saastamoinen, Kenichi Nagano, Roland Baron, RikuKiviranta. Early B-cell Factor1 (Ebf1) promotes early osteoblast differentiation but suppresses osteoblast function. Bone.  2021 May;146:115884. doi: 10.1016/j.bone.2021.115884.

8. [Short Report] Eben G. Estell, Phuong T. Le, Yosta Vegting, Hyeonwoo Kim, Christiane Wrann, Mary L. Bouxsein, Kenichi Nagano, Roland Baron, Bruce Spiegelman, Clifford J. Rosen. Irisin Directly Stimulates Osteoclastogenesis and Bone Resorption In Vitro and In Vivo. 2020 Aug 11;9:e58172. doi: 10.7554/eLife.58172.

9. Shuichi Fujita, Misa Sumi, Eri Tatsukawa, Kenichi Nagano, Naoki Katase. Expressions of Extracellular Matrix-Remodeling Factors in Lymph Nodes From Oral Cancer Patients. 2020 Oct;26(7):1424-1431. doi: 10.1111/odi.13419.

10. Sutada Lotinun, Yoshihito Ishihara, Kenichi Nagano, Riku Kiviranta, Vincent Carpentier, Lynn Neff, Virginia Parkman, Noriko Ide, Dorothy Hu, Pamela Dann, Daniel Brooks, Mary L. Bouxsein, John Wysolmerski, Francesca Gori, and Roland Baron. Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression. . 2019 May 21;129(8):3058-3071. doi: 10.1172/JCI122936.

11. [Review Article] Kenichi Nagano. R-spondin signaling as a pivotal regulator of tissue development and homeostasis.. 2019 Nov;55(1):80-87. doi: 10.1016/j.jdsr.2019.03.001.

12. Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald and Bruce M. Spiegelman. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.. 2018 Dec 13;175(7):1756-1768.e17. doi: 10.1016/j.cell.2018.10.025.

13. Shokichi Tsukamoto, Marianne B. Løvendorf, Jihye Park, Karma Z. Salem, Michaela R. Reagan, Salomon Manier, Oksana Zavidij, Mahshid Rahmat, Daisy Huynh, Satoshi Takagi, Yawara Kawano, Katsutoshi Kokubun, Charlotte Albæk Thrue, Kenichi Nagano, Andreas Petri, Aldo M. Roccaro, Marzia Capelletti, Roland Baron, Sakari Kauppinen, Irene M. Ghobrial. Inhibition of microRNA-138 enhances bone formation in multiple myeloma bone marrow niche. 2018 Aug;32(8):1739-1750. doi: 10.1038/s41375-018-0161-6.

14. Hirotaka Komaba, Jovana Kaludjerovic, Dorothy Zhang Hu, Kenichi Nagano, Katsuhiko Amano, Noriko Ide, Tadatoshi Sato, Michael Joseph Densmore, Jun-ichi Hanai, Hannes Olauson, Tobias Erik Larsson, Roland Baron, Beate Lanske. Klotho expression in osteocytes regulates bone metabolism and controls bone formation. 2017 Sep;92(3):599-611. doi: 10.1016/j.kint.2017.02.014.

15. David E Maridas, Victoria E DeMambro, Phuong T Le, Kenichi Nagano, Roland Baron, Subburaman Mohan and Clifford J Rosen. IGFBP-4 regulates adult skeletal growth in a sex-specific manner. 2017 Apr;233(1):131-144. doi: 10.1530/JOE-16-0673.

16. Marc Wein, Yanke Liang, Olga Goransson, Thomas Sundberg, Jinhua Wang, Elizabeth Williams, Maureen O'Meara, Nicolas Govea, Belinda Beqo, Shigeki Nishimori, Kenichi Nagano, Daniel Brooks, Janaina Martins, Braden Corbin, Anthony Anselmo, Ruslan Sadreyev, Joy Wu, Kei Sakamoto, Marc Foretz, Ramnik Xavier, Roland Baron, Mary Bouxsein, Thomas Gardella, Paola Divieti Pajevic, Nathanael Gray, and Henry Kronenberg. Salt Inducible Kinases (SIKs) control osteocyte responses to parathyroid hormone. 2016 Oct 19;7:13176. doi: 10.1038/ncomms13176.

17. Detina Zalli, Lynn Neff, Kenichi Nagano, Nah Young Shin, Walter Witke, Francesca Gori and Roland Baron. The actin-binding protein Cofilin and its interaction with Cortactin are required for podosome patterning in osteoclasts and bone resorption in vivo and in vitro. . 2016 Sep;31(9):1701-12. doi: 10.1002/jbmr.2851.

18. Yukari Shiwaku, Lynn Neff, Kenichi Nagano, Ken-Ichi Takeyama, Joost De Bruijn, Michel Dard, Francesca Gori, and Roland Baron. The Crosstalk between Osteoclasts and Osteoblasts is Dependent Upon the Composition and Structure of Biphasic Calcium Phosphates. 2015 Jul 20;10(7):e0132903. doi: 10.1371/journal.pone.0132903.

19. Toshimi Sato, Neil Alles, Masud Khan, Kenichi Nagano, Mariko Takahashi, Yukihiko Tamura, Asako Shimoda, Keiichi Ohya, Kazunari Akiyoshi, Kazuhiro Aoki. Nanogel-crosslinked nanoparticles increase the inhibitory effects of W9 synthetic peptide on bone loss in a murine bone resorption model.. 2015 May 11;10:3459-73. doi: 10.2147/IJN.S61566.

20. Sofia Movérare-Skrtic, Petra Henning, Xianwen Liu, Kenichi Nagano, Hiroaki Saito, Anna E. Börjesson, Klara Sjögren, Sara H. Windahl, Helen Farman, Bert Kindlund, Cecilia Engdahl, Antti Koskela, Fu-Ping Zhang, Emma E. Eriksson, Farasat Zaman, Ann Hammarstedt, Hanna Isaksson, Marta Bally, Ali Kassem, Catharina Lindholm, Olof Sandberg, Per Aspenberg, Lars Sävendahl, Jiang Q. Feng, Jan Tuckermann, Juha Tuukkanen, Matti Poutanen, Roland Baron, Ulf H. Lerner, Francesca Gori and Claes Ohlsson. Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures. 2014 Nov;20(11):1279-88. doi: 10.1038/nm.3654.

21. Archana Swami, Michaela R. Reagan, Pamela Basto, Yuji Mishima, Nazila Kamaly, Siobhan Glavey, Sufeng Zhang, Michele Moschetta, Dushanth Seevaratnam, Yong Zhang, Jinhe Liu, Tina Memarzadeh, Jun Wu, Salomon Manier, Jinjun Shi, Nicolas Bertrand, Zhi Ning Lu, Kenichi Nagano, Roland Baron, Antonio Sacco, Aldo M. Roccaro, Omid C. Farokhzad, Irene M. Ghobrial. Engineered Nanomedicine for Myeloma and Bone Microenvironment Targeting. 2014 Jul 15;111(28):10287-92. doi: 10.1073/pnas.1401337111.

22. Abdulla Al Masud Khan, Neil Alles, Niroshani S. Soysa, Md. Abdullah Al Mamun, Kenichi Nagano, Risako Mikami, Yuriko Furuya, Hisataka Yasuda, Keiichi Ohya, Kazuhiro Aoki. The local administration of TNF-α and RANKL antagonist peptide promotes BMP-2-induced bone formation. Journal of Oral Biosciences. 55:47–54, 2013. doi.org/10.1016/j.job.2012.12.005.

23. Hitomi Nakamura, Kazuhiro Aoki, Wataru Masuda, Neil Alles, Kenichi Nagano, Hidefumi Fukushima, Kenji Osawa, Hisataka Yasuda, Ichiro Nakamura, Yuko Mikuni-Takagaki, Keiichi Ohya, Kenshi Maki, Eijiro Jimi. Disruption of NF-κB1 prevents bone loss caused by mechanical unloading. 2013 Jun;28(6):1457-67. doi: 10.1002/jbmr.1866.

24. Hiroyuki Nakachi, Kazuhiro Aoki, Nobuyoshi Tomomatsu, Neil Alles, Kenichi Nagano, Masashi Yamashiro, Hongtao Zhang, Ramachandran Murali, Mark I. Greene, Keiichi Ohya and Teruo Amagasa. A structural modulator of tumor necrosis factor type 1 receptor promotes bone formation under lipopolysaccharide-induced inflammation in a murine tooth extraction model. . 2012 Mar 15;679(1-3):132-8. doi: 10.1016/j.ejphar.2011.12.046.

25. Yoshinori Seo, Hidefumi Fukushima, Toshimasa Maruyama, Kayoko Nakao Kuroishi, Kenji Osawa, Kenichi Nagano, Kazuhiro Aoki, Falk Weih, Takahiro Doi, Min Zhang, Keiichi Ohya, Takenobu Katagiri, Ryuji Hosokawa and Eijiro Jimi. Accumulation of p100, a Precursor of NF-κB2, Enhances Osteoblastic Differentiation in Vitro and Bone Formation in Vivo in aly/aly Mice. Molecular Endocrinology. 2012 Mar;26(3):414-22. doi: 10.1210/me.2011-1241.

26. Kenichi Nagano, Neil Alles, Anower Hussain Mian, Asako Shimoda, Nobuyuki Morimoto, Yukihiko Tamura, Hitoyata Shimokawa, Kazunari Akiyoshi, Keiichi Ohya and Kazuhiro Aoki. The tumor necrosis factor type 2 receptor plays a protective role in tumor necrosis factor-α-induced bone resorption lacunae on mouse calvariae. Journal of Bone and Mineral Metabolism. 2011 Nov;29(6):671-81. doi: 10.1007/s00774-011-0270-z. [SCIE. Impact Factor (2022); 3.3]

27. Michio Onizawa, Takashi Nagaishi, Takanori Kanai, Kenichi Nagano, Shigeru Oshima, Yasuhiro Nemoto, Atsushi Yoshioka, Teruji Totsuka, Ryuichi Okamoto, Tetsuya Nakamura, Naoya Sakamoto, Kiichiro Tsuchiya, Kazuhiro Aoki, Keiichi Ohya, Hideo Yagita and Mamoru Watanabe. Signaling pathway via TNF-α/NF-κB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis. American Journal of Physiology - Gastrointestinal and Liver Physiology.  2009 Apr;296(4):G850-9. doi: 10.1152/ajpgi.00071.2008.

他、計47報

＜研究費獲得状況＞

1. （研究代表者）日本学術振興会 科研費 基盤研究(C)　2025年4月- 2029年3月 
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2. （研究代表者）一般社団法人 日本骨代謝学会年度若手研究者助成（The JSBMR Rising Star Grant）2024年9月-2025年3月
                      　骨代謝動態が示す部位特異性の解明　500千円

3. （研究代表者）一般財団法人 輔仁会 令和6年度医学・歯学の教育研究の奨励助成金  2024年9月-2025年3月
                         長管骨と腰椎骨における骨代謝動態の差異の解明　500千円

4. （研究分担者）日本学術振興会 科研費 基盤研究(C)　2023年4月-2026年3月　
                         変異型Rufy4を発現する破骨細胞の細胞外小胞を介した骨吸収調節機構の解明と応用　150千円

5. （研究分担者）日本学術振興会 科研費 国際共同研究強化(B)　2022年10月-2027年3月
                         新たな骨再生医療創成に向けた間葉系幹細胞の再定義とエネルギーセンシング機構の解明　300千円

6. （研究代表者）一般財団法人 輔仁会 令和4年度医学・歯学の教育研究の奨励助成金 2022年6月-2023年3月
                        骨代謝制御においてWnt signal間クロストークが果たす役割の解明 500千円

7. （研究分担者）日本学術振興会 科研費 基盤研究(C)　2022年4月-2027年3月
                         ROSシグナルの挙動と反応不均一性を解明し新規フラボノイドによる骨再生を目指す 250千円　

8. （研究分担者）日本学術振興会 科研費 基盤研究(C) 2021年4月-2024年3月
                         細胞骨格関連分子Kidによる骨・軟骨代謝制御機構の解明 250千円　

9. （研究分担者）日本学術振興会 科研費 基盤研究(C)  2021年4月-2023年3月
                         小児骨粗しょう症治療を見据えた顎顔面発達におけるBMP3の役割  150千円　

10. （研究分担者）日本学術振興会 科学研究費助成事業 基盤研究(C) 2020年4月-2023年3月
                          アミノ酸センサーうま味受容体が担う悪性黒色腫の増殖・浸潤・遠隔転移機構の解明　400千円

11. （研究代表者）日本学術振興会 科研費 基盤研究(C)  2019年4月-2022年3月
                          Runx2とWnt signalによる骨芽細胞分化・機能制御の解明　4,420千円

12. （研究代表者）公益財団法人 薬力学研究会 薬力学研究会研究助成金  2012年4月-2013年3月
                          腫瘍壊死因子2型受容体を標的とした新規炎症性骨吸収治療薬の開発に関する研究

＜出版＞

1. 歯科衛生士・歯科助手 おしごとハンドブック発売コード：（分担執筆）

＜受賞＞

1. 2018 ASBMR Young Investigator Award, アメリカ骨代謝学会　2018年9月

2. 第51回歯科基礎医学会年会 優秀ポスター賞, 歯科基礎医学会, 2009年9月​